Role of Immunohistochemistry Markers (p53 and CEA), in Study of Colorectal Tumours

Colorectal cancer is the third most common in men and second women globally. There a marked variation incidence of colorectal carcinoma worldwide, where western countries having high rate compared to others. p53 tumour suppressor gene one intensively studied markers tumours. Two were used, (oncoprotein p53) CEA (carcinoembryonic antigen) study. The 102 cases paraffin-embedded samples processed for immunohistochemistry examination. After analysis selected patients regarding antibodies distribution, statistical was performed. current study showed that there statistically significant correlation existing between each type irrespective its histological grades. (IHC) performed on 4-µm thick sections from 10% formalin- fixed tissue blocks.